Kutshanje, inqaku lephephandaba leGunma University School of Medicine yaseJapan lanikela ingxelo yokuba isibhedlele sibangele icyanosis kwinani leentsana ezisandul’ ukuzalwa ngenxa yokungcoliswa kwamanzi etephu. Uphononongo lubonisa ukuba kwanamanzi ahluziweyo anokungcoliswa ngempazamo kwaye iintsana zisengozini enkulu yokuba ne-methemoglobinemia.
Ukuqhambuka kwe-Methemoglobinemia kwi-ICU yosana kunye neWadi yokubeleka
Ishumi labantwana abasandul’ ukuzalwa kwigumbi labagula kakhulu kunye newadi yababeleki baye baba ne-methemoglobinemia ngenxa yokutyiswa ubisi olungumgubo oluxutywe namanzi etephu angcolileyo. Uxinzelelo lwe-methemoglobin lusuka kwi-9.9% ukuya kwi-43.3%. Izigulane ezintathu zafumana i-methylene eluhlaza okwesibhakabhaka (utolo), ebuyisela amandla okuphatha i-oksijini ye-hemoglobin, kwaye emva kweeyure ezisithoba, zonke izigulane ze-10 zibuyele kwisiqhelo ngokuqhelekileyo. Umzobo B ubonisa umzobo wevalve eyonakalisiweyo kunye nomsebenzi wayo oqhelekileyo. Umzobo C ubonisa ubudlelwane phakathi kokunikezelwa kwamanzi okusela kunye nombhobho ojikelezayo wokufudumeza. Amanzi okusela esibhedlele aphuma equleni kwaye adlula kwinkqubo yokucoca kunye nesihluzo sokubulala iintsholongwane. Umgca wokujikeleza wokufudumeza uhlukaniswe nokunikezelwa kwamanzi okusela nge-valve yokukhangela. Ukungaphumeleli kwe-valve yokutshekisha kubangela ukuba amanzi abuyele kumgca wokujikeleza kokufudumala ukuya kumgca wokuhambisa amanzi okusela.
Uhlalutyo lwamanzi epompo lubonise umxholo ophezulu we-nitrite. Emva kophando oluthe kratya, safumanisa ukuba amanzi okusela angcolisekile ngenxa yokungaphumeleli kwevalvu okubangelwa kukubuyela umva kwenkqubo yokufudumeza esibhedlele. Amanzi kwisistim sokufudumeza aqukethe izigcini (Amanani 1B kunye ne-1C). Nangona amanzi etephu asetyenziswa xa kusenziwa ubisi olungumgubo lweentsana acociweyo ngezihluzo ukuze ahlangabezane nemigangatho yelizwe, izihluzo azikwazi ukuphelisa iinitrites. Enyanisweni, amanzi aphuma etephini kuso sonke isibhedlele ayengcolisekile, kodwa akukho namnye kwaba bakhulileyo owaba nemethemoglobin.
Xa kuthelekiswa nabantwana abadala kunye nabantu abadala, iintsana ezingaphantsi kweenyanga ezi-2 zisengozini yokufumana i-methemoglobinosis kuba iintsana zisela amanzi amaninzi ngekhilogram yobunzima bomzimba kwaye zinomsebenzi omncinci we-NADH cytochrome b5 reductase, oguqula i-methemoglobin ibe yi-hemoglobin. Ukongezelela, i-pH ephezulu kwisisu somntwana ibangela ukuba kubekho iibhaktheriya zokunciphisa i-nitrate kwindawo ephezulu yokugaya, eguqula i-nitrate kwi-nitrite.
Eli tyala libonisa ukuba naxa umgubo ulungiswa kusetyenziswa amanzi ahluzwe ngokufanelekileyo, imethemoglobin inokubangelwa kukungcoliswa kwamanzi ngempazamo. Ukongezelela, le meko igxininisa into yokuba iintsana zisengozini ngakumbi kwi-methemoglobin kunabantu abadala. Ukuqaphela ezi zinto kubalulekile ekuchongeni umthombo we-methemoglobin kunye nokunciphisa umda wokuqhambuka kwayo.
Ixesha lokuposa: Mar-09-2024