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Okwangoku, i-imaging magnetic resonance imaging (MRI) iyaphuhla ukusuka kwi-imaging ye-structural yendabuko kunye nemifanekiso esebenzayo ukuya kwi-imaging molecular. I-Multi-nuclear MR Ingakwazi ukufumana ulwazi oluninzi lwe-metabolite emzimbeni womntu, ngelixa igcina isisombululo sendawo, iphucula ngokukodwa ukufunyanwa kweenkqubo ze-physiological kunye ne-pathological, kwaye okwangoku iteknoloji yodwa engakwazi ukuhlalutya ubuninzi be-non-invasive quantitative analysis of human dynamic dynamic molecular metabolism in vivo.

Ngokunzulu koPhando lwe-MR olune-multi-core, lunamathuba okusebenza okubanzi ekuhlolweni kwangaphambili kunye nokuxilongwa kwamathumba, izifo zentliziyo, izifo ze-neurodeergenerative, inkqubo ye-endocrine, inkqubo yokugaya kunye nezifo zenkqubo yokuphefumla, kunye novavanyo olukhawulezayo lwenkqubo yonyango. Iqonga likaPhilips lamva nje elinesiseko sophando lweklinikhi liya kunceda ukucinga kunye noogqirha beklinikhi ukuba benze uphando lweklinikhi oluphambili. UGqr. Sun Peng kunye noGqr. Wang Jiazheng ovela kwiSebe leNkxaso yezoNyango lwePhilips banike isingeniso esicacileyo kuphuhliso lwe-multi-NMR kunye nesikhokelo sophando se-Philips 'esitsha se-MR Platform.

I-Magnetic resonance iphumelele iBhaso likaNobel izihlandlo ezihlanu kwimbali yayo, kuwo wonke amasimi efiziksi, ikhemistri, ibhayoloji, kunye neyeza, kwaye iphumelele impumelelo enkulu kwimigaqo esisiseko yefiziksi, ubume bemolekyuli yendalo, ubume bebhayoloji bemacromolecular dynamics, kunye nokucinga kwezonyango. Phakathi kwabo, i-imaging resonance imaging iye yaba yenye yezona teknoloji zibalulekileyo zokujonga unyango lwezonyango, ezisetyenziswa ngokubanzi ekuxilongeni izifo ezahlukahlukeneyo kwiindawo ezahlukeneyo zomzimba womntu. Ngokuphuculwa okuqhubekayo kweemfuno zokunakekelwa kwezempilo, imfuno enkulu yokuxilongwa kwangaphambili kunye novavanyo olukhawulezayo olukhawulezayo lukhuthaza ukuphuhliswa kwe-imaging magnetic resonance i-imaging ye-structural imaging (T1w, T2w, PDw, njl.), umfanekiso osebenzayo (i-DWI, i-PWI, njl.) kwi-imaging ye-molecular (1H MRS kunye ne-multi-core MRS / MRI).

Imvelaphi eyinkimbinkimbi ye-1H esekelwe kwi-MR Technology, i-spectra edibeneyo, kunye nokunyanzeliswa kwamanzi / ukunyanzeliswa kwamafutha kunciphisa indawo yayo njengeteknoloji ye-imaging ye-molecular. Kuphela inani eliqingqiweyo leemolekyuli (i-choline, i-creatine, i-NAA, njl.) inokufunyanwa, kwaye kunzima ukufumana iinkqubo ze-molecular metabolic metabolic. Ngokusekwe kwiindidi zenuclides (23Na, 31P, 13C, 129Xe, 17O, 7Li, 19F, 3H, 2H), multi-nuclear MR Unokufumana ulwazi oluninzi lwe-metabolite yomzimba womntu, kunye nesisombululo esiphezulu kunye neenkcukacha eziphezulu, kwaye okwangoku kuphela kwe-non-invasive, i-stable metabolite ye-isolitestope ye-isolitestope; (i-glucose, i-amino acids, i-fatty acids - i-non-toxic) ukwenzela uhlalutyo lobungakanani beenkqubo ze-molecular dynamic metabolic.

Ngokuphumelela okuqhubekayo kwinkqubo ye-hardware ye-magnetic resonance, indlela yokulandelelana ngokukhawuleza (i-Multi-Band, i-Spiral) kunye ne-algorithm yokukhawuleza (i-compressed sensing, ukufunda okunzulu), i-multi-core MR Imaging / spectroscopy ikhula ngokuthe ngcembe: (1) kulindeleke ukuba ibe sisixhobo esibalulekileyo sokusika i-biology ye-molecular, i-biochemistry kunye nophando lwemetabolism yabantu; (2) Njengoko isuka kuphando lwezesayensi ukuya kwiikliniki (inani lezilingo zekliniki ezisekelwe kwi-MR eninzi ziyaqhubeka, i-FIG. 1), inamathemba abanzi ekuhlolweni kwangaphambili kunye nokuxilongwa komhlaza, i-cardiovascular, neurodegenerative, digestive and breathing, kunye nokuvavanya ngokukhawuleza ukuphumelela.

Ngenxa yemigaqo enzima yomzimba kunye nobunzima obuphezulu bezobugcisa be-MR Field, i-multi-core MR ibe yindawo yophando ekhethekileyo yamaziko ambalwa aphezulu ophando lobunjineli. Nangona i-multicore MR Yenze inkqubela phambili ebonakalayo emva kwamashumi eminyaka yophuhliso, kusekho ukunqongophala kwedatha yeklinikhi eyaneleyo yokuqhubela phambili le ntsimi ukuze incede izigulane ngokwenene.

Ngokusekwe kubutsha obuzingisileyo kwintsimi ye-MR, uPhilips ekugqibeleni waphula ibhotile yophuhliso lwe-multi-core MR Kwaye wakhupha iqonga elitsha lophando lweklinikhi kunye neyona nuclides kwishishini. Iqonga likuphela kwenkqubo ye-multi-core kwihlabathi ukufumana i-EU yoKhuseleko lokuThotyelwa kweSiqinisekiso (CE) kunye ne-US Food and Drug Administration (FDA) isiqinisekiso, esenza ukuba imveliso-inqanaba elipheleleyo le-MR Isisombululo esigcweleyo se-MR: iikhoyili ezivunyiweyo ze-FDA, ulandelelwano olupheleleyo, kunye nokwakhiwa kwakhona komgangatho wesikhululo sabaqhubi. Abasebenzisi akufuneki baxhotyiswe ngeengcali zenzululwazi yeresonance yemagnethi, iinjineli zekhowudi kunye nabayili be-RF gradient, elula kune-1H yesiqhelo ispectroscopy/imaging. Ukwandisa ukuncitshiswa kweendleko zokuSebenza ze-MR ezininzi ezingundoqo, ukutshintsha kwamahhala phakathi kophando lwezenzululwazi kunye nemodi yeklinikhi, ukubuyiswa kweendleko ngokukhawuleza, ukwenzela ukuba i-multi-core MR Ngokwenene kwikliniki.

I-Multi-core MR ngoku isalathiso esiphambili se-"14th yeminyaka emihlanu yeSicwangciso soPhuhliso lweZixhobo zoNyango lweZixhobo zoNyango", kwaye iyitekhnoloji engundoqo ephambili yokucinga ngezonyango ukuze iqhekeze inkqubo kwaye idibanise ne-cutting-edge biomedicine. Iqela lezazinzulu zePhilips China, eliqhutywa kukuphucula uphando lwezenzululwazi lwabathengi kunye nobuchule bokuqamba izinto ezintsha, lenze uphando olucwangcisiweyo kwi-multi-core MR. UGqr Sun Peng, uGqr. Wang Jiazheng et al. kuqala ucebise ingqiqo ye-MR-nucleomics kwi-NMR kwi-Biomedicine (i-Journal ephezulu yoMmandla wokuQala we-Spectroscopy ye-Chinese Academy of Sciences), enokusebenzisa i-MR Ngokusekelwe kwiinuclides ezahlukeneyo ukujonga imisebenzi eyahlukeneyo yeeseli kunye neenkqubo ze-pathological. Ke, isigwebo esibanzi kunye novavanyo lwesifo kunye nonyango lunokwenziwa [1]. Ingqikelelo ye-MR Multinucleomics iya kuba ngumkhombandlela wexesha elizayo woPhuhliso lwe-MR. Eli phepha liyinkqubo yokuqala yokuphononongwa kwe-multi-core MR Ehlabathini, equka isiseko sethiyori ye-multi-core MR, uphando lwangaphambili lweklinikhi, ukuguqulwa kweklinikhi, ukuphuhliswa kwe-hardware, inkqubela ye-algorithm, ubunjineli bobunjineli kunye nezinye iinkalo (Umfanekiso 2). Kwangaxeshanye, iqela lezazinzulu basebenzisane kunye noNjingalwazi Song Bin weSibhedlele sase-West China ukugqiba inqaku lokuqala lokuphonononga malunga nokuguqulwa kwekliniki ye-multi-core MR e-China, eyapapashwa kwiphephancwadi i-Insights kwi-Imaging [2]. Ukupapashwa kothotho lwamanqaku kwimulticore MR Ibonisa ukuba iPhilips izisa ngokwenene umda wokucinga ngeemolekyuli ezininzi eTshayina, kubathengi baseTshayina, nakwizigulana zaseTshayina. Ngokuhambelana nombono ongundoqo othi "e-China, e-China", i-Philips iya kusebenzisa i-multi-core MR Ukukhuthaza ukuphuhliswa kwe-resonance magnetic yase-China kunye nokunceda imbangela ye-China enempilo.

I-Multi-nuclear MRI yiteknoloji evelayo. Ngokuphuhliswa kwe-MR Software kunye ne-hardware, i-MRI ye-nuclear eninzi isetyenzisiwe kuphando olusisiseko kunye neklinikhi yokuguqulela iinkqubo zoluntu. Inzuzo yayo ekhethekileyo kukuba inokubonisa iinkqubo zemetabolism ngexesha lokwenyani kwiinkqubo ezahlukeneyo ze-pathological, ngaloo ndlela ibonelela ngamathuba okuxilongwa kwangoko kwezifo, ukuvavanya ukusebenza kakuhle, ukwenza izigqibo zonyango kunye nophuhliso lwamachiza. Kusenokunceda ukuphonononga iindlela ezintsha ze-pathogenesis.

Ukuze kukhuthazwe uphuhliso olongezelelweyo lwale ntsimi, ukuthatha inxaxheba okusebenzayo kweengcali zeklinikhi kuyadingeka. Uphuhliso lonyango lwamaqonga amaninzi lubalulekile, kubandakanya ukwakhiwa kweenkqubo ezisisiseko, ukubekwa emgangathweni kobuchwephesha, ubungakanani kunye nokubekwa emgangathweni kweziphumo, ukuphononongwa kophando olutsha, ukudityaniswa kolwazi oluninzi lwe-metabolic, njl. Sikholelwa ngokuqinisekileyo ukuba i-multi-core MR iya kubonelela ngenqanaba elibanzi lokucinga kunye neengcali zeklinikhi ukwenza uphando lweklinikhi, kwaye iziphumo zayo ziya kunceda izigulane emhlabeni jikelele.